AI for Disease Prediction & Early Diagnosis
Welcome to Dr. Jo's Medical AI Research Lab
LatestResearch Tools
AI platforms for Alzheimer's disease genomics and systematic review screening
DuAL-Net
Dual Approach Local-global Network
Hybrid framework combining local and global genomic features for AD prediction from WGS.
TrUE-Net
Transformer Uncertainty Ensemble
Uncertainty-aware genomic deep learning framework using transformer ensembles for AD classification.
SWAT-web
Sliding Window Association Test
Genome-wide sliding window association analysis of whole-genome sequencing data using deep learning.
ReviewFast
AI Screening for Systematic Reviews
Ranks search results against a review's eligibility criteria, then supports screening, stopping, and data extraction.
Latest Publications
Recent publications and preprints
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2026
Case-Enriched Rare Variants in Alzheimer's Disease Show Higher Predicted Regulatory Impact
Jo*, ..., Nho*, Saykin* 路 Cell Reports Accepted
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2026
Label-free, Low-cost AI Ranking for Systematic Review Screening
Jo*, Lee, Lee 路 medRxiv
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2026
DuAL-Net: A Hybrid Deep Learning Framework for Alzheimer's Disease Prediction from Whole-Genome Sequencing
Lee & Jo* 路 Computational and Structural Biotechnology Journal
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2025
Uncertainty-Aware Genomic Deep Learning Classification of Alzheimer's Disease
Jo* & Lee 路 Briefings in Bioinformatics
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2025
Longitudinal Plasma Proteomics in Alzheimer's Disease
Lee, ..., Saykin*, Jo*, Nho* 路 Alzheimer's & Dementia
Research Areas
Core research themes of our lab
Genomics & AI
We combine large-scale genomic data with AI to identify genetic variants linked to Alzheimer's disease, helping identify individuals at higher risk more accurately.
Neuroimaging & AI
Combining brain imaging technologies like PET and MRI with AI to detect early changes in the brain associated with Alzheimer's before symptoms appear.
Metabolomics / Proteomics & AI
Analyzing metabolites and proteins in biological fluids to track biochemical changes as Alzheimer's progresses, predicting progression before cognitive decline begins.
Precision Medicine
Integrating genomics, neuroimaging, and metabolomics with AI to develop precise predictions of disease progression and personalized treatment strategies.
Evidence Synthesis & AI
Using low-cost AI to rank search results for systematic reviews, the evidence behind clinical guidelines, so that reviewers find the relevant studies with far less screening.
Global Mental Health & AI
Building a digital monitoring platform with Massachusetts General Hospital and Makerere University to help clinicians in Uganda deliver clozapine safely for treatment-resistant schizophrenia.
Research in Use
Researchers around the world are using ReviewFast, Jo Lab's AI screening tool for systematic reviews
Research Support
